Pain is felt in different ways dependent on a variety of factors
Everyone experiences pain in different ways so understanding the types of pain can help you when speaking with your doctor. Some pain is obvious and directly related to injury or musculoskeletal issues. Specifically, neuropathic pain, an outcome of those with PAD or Diabetic Neuropathy, is experienced due to tissue damage caused by a lack of blood flow to the extremities.
Opioids are generally not recommended as a first line of treatment for PAD associated neuropathic, generally caused by the narrowing of the arteries and constricted blood flow. PAD associated pain can be severe and nearly 25% of all those with PAD are at risk for addiction when being prescribed opioids to treat chronic neuropathic. Opioids should only be used as a second-line of treatment for those with PAD associated neuropathic. Currently, there are no known treatments for PAD or Diabetic Neuropathy, thus many live long-term with the resulting neuropathic. But, the pain can be alleviated with diet and other lifestyle changes as well as non-opioid based treatments such as:
- Amitriptyline – also used for treatment of headaches and depression
- Suloxetine – also used for treatment of bladder problems and depression
- Pregabalin and gabapentin – also used to treat epilepsy, headaches or anxiety
Only your doctor can determine the best way to treat PAD associated neuropathic but the use of opioids should be avoided. At JanOne, the premise of JAN101, the PAD treatment currently in our pipeline, is the use of nitrites to reverse constriction of the arteries, repair damaged arterial tissues and increase blood flow to near normal function. This, in turn, has the potential to remediate PAD neuropathic. That means less risk for opioid abuse at the prescription pad.